Researchers create mandibles from stem cells

DoroWalz By DoroWalz, 16th Mar 2013 | Follow this author | RSS Feed | Short URL
Posted in Wikinut>News>Science

A recent follow-up study on humans reveals that mesenchymal stem cells are a proper candidate for regenerating lost mandible bone tissue.


A team of researchers released a new interesting follow up study on human patients that had received three ago a stem cell transplant with the purpose to regenerate lost bone tissue in their mandibles. Their bone loss was the result of a previous molar extraction. The study is very interesting as the transplanted cells succesfully regenerated all the lost bone!


As aforementioned, this study is a follow up. About three years ago (2009), the study's participants received a graft that was mainly comprised by two things. A collagenous scaffold that had been previously seed with autologous mesenchymal stem cells that were extracted from dental pulp (visible in the attached image). All patients receiving the graft presented with severe bone loss, which was the result of having in the past their third molar extracted.

The results

The study's first important finding is that in all cases the stem cell transplant resulted in bone regeneration, fully filling the defects.

The second and most interesting finding is that the newly regenerated bone wasn't the same as the one we originally have. It was a lot more dense, however it seemed to be both healthy and vascularized. Thee researchers say that this might actually be an advantage as the grafts seemed to be stadier and more stable! The researchers believe that this is due to the mesenchymal stem cells being unable to follow the local signals of the surrounding tissue.

Furthermore, no serious adverse effects were reported including:
- Tissue rejection
- Morbidity
- Infection
- Swelling


- Three Years After Transplants in Human Mandibles, Histological and In-Line Holotomography Revealed That Stem Cells Regenerated a Compact Rather Than a Spongy Bone: Biological and Clinical Implications
- Stem cells generate long standing human mandibles


Mandible, Mesenchymal Stem Cells, Stem Cells

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author avatar DoroWalz
I will be writting for medical-related thingies ! :)

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